Download Exploring the Vertebrate Central Cholinergic Nervous System PDF

Exploring the Vertebrate Central Cholinergic Nervous System

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Publisher : Springer Science & Business Media
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ISBN 10 : 9780387465265
Pages : 698 pages
Rating : 4.4/5 (387 users)

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Download or read book Exploring the Vertebrate Central Cholinergic Nervous System PDF or another Format written by Alexander G. Karczmar and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.


Download Exploring the Vertebrate Central Cholinergic Nervous System PDF

Exploring the Vertebrate Central Cholinergic Nervous System

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Publisher : Springer
Release Date :
ISBN 10 : 0387282238
Pages : 698 pages
Rating : 4.2/5 (282 users)

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Download or read book Exploring the Vertebrate Central Cholinergic Nervous System PDF or another Format written by Alexander G. Karczmar and published by Springer. This book was released on 2006-10-04 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.


Download Chemical Biology of Neurodegeneration PDF

Chemical Biology of Neurodegeneration

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Publisher : John Wiley & Sons
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ISBN 10 : 9783527813438
Pages : 384 pages
Rating : 4.8/5 (527 users)

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Download or read book Chemical Biology of Neurodegeneration PDF or another Format written by Pedro Merino and published by John Wiley & Sons. This book was released on 2019-08-07 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.


Download Liver Disease and Surgery PDF

Liver Disease and Surgery

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Publisher : BoD – Books on Demand
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ISBN 10 : 9781789850659
Pages : 248 pages
Rating : 4.8/5 (789 users)

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Download or read book Liver Disease and Surgery PDF or another Format written by Georgios Tsoulfas and published by BoD – Books on Demand. This book was released on 2019-11-27 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to present a review of the different categories of liver disease, as well as address the role of surgery in managing these complex diseases. The book includes chapters written by international experts on the most current indications and guidelines regarding the diagnoses and management of liver diseases, as well as a variety of technical elements involved with the surgical procedures. Different surgical techniques involved in performing a hepatectomy will be discussed, including various instruments used, as well as the effect of modern technology as evidenced by novel procedures. An important focus of the book has been identifying the proper place of all these hepatectomy methods in the armamentarium of the experienced hepatobiliary surgeon, including the role of locoregional treatments such as ablation and embolization as adjuncts. Finally, the role of hepatectomy compared to orthotopic liver transplantation is discussed, so that the reader can have a well-rounded picture of the challenges and opportunities involved. Overall, this book has the potential to serve as an invaluable "tool" for both the hepatologist and the internist, as well as for the hepatic surgeon


Download Mammalian Toxicology of Insecticides PDF

Mammalian Toxicology of Insecticides

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Publisher : Royal Society of Chemistry
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ISBN 10 : 9781849733007
Pages : 506 pages
Rating : 4.7/5 (849 users)

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Download or read book Mammalian Toxicology of Insecticides PDF or another Format written by Tim Marrs and published by Royal Society of Chemistry. This book was released on 2012-01-19 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insects more similar in structure and physiology to mammals than plants or fungi. Consequently, insecticides are often of greater toxicity to mammals than herbicides. This is particularly the case with neurotoxins. However, some insecticides are targeted at structures or hormonal systems specific to insects (insect growth regulators/chitin synthesis inhibitors) so are less harmful but can still be mildly haematotoxic. There are, therefore, issues specific to insecticides, which do not occur with other pesticides - hence the need for a book specifically on insecticide toxicology in mammals. The book starts with general issues relating to the mammalian toxicity of insecticides, including target/non-target specificity, nomenclature and metabolism of insecticides. It then goes on to discuss specific types of insecticide including: organochlorines; anticholinesterases; pyrethrum and synthetic pyrethroids; nicotine and the neonicotinoids; insect growth regulators/ecdysone agonists/chitin synthesis inhibitors; insecticides of natural origin; biological insecticides; and insecticides used in veterinary medicine.


Download Basic and Clinical Toxicology of Organophosphorus Compounds PDF

Basic and Clinical Toxicology of Organophosphorus Compounds

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781447156253
Pages : 257 pages
Rating : 4.1/5 (447 users)

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Download or read book Basic and Clinical Toxicology of Organophosphorus Compounds PDF or another Format written by Mahdi Balali-Mood and published by Springer Science & Business Media. This book was released on 2013-12-19 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.


Download Neurotoxicity of Pesticides PDF

Neurotoxicity of Pesticides

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Publisher : Academic Press
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ISBN 10 : 9780128205150
Pages : 300 pages
Rating : 4.2/5 (128 users)

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Download or read book Neurotoxicity of Pesticides PDF or another Format written by Michael Aschner and published by Academic Press. This book was released on 2020-04 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others.


Download Neurotransmitters in Plants PDF

Neurotransmitters in Plants

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Publisher : CRC Press
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ISBN 10 : 9781351360418
Pages : 424 pages
Rating : 4.3/5 (351 users)

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Download or read book Neurotransmitters in Plants PDF or another Format written by Akula Ramakrishna and published by CRC Press. This book was released on 2018-09-19 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: New scientific data confirm the origin of neurotransmitters in the ancient ocean, whose inhabitants use the compounds in their relationships. One example is the algae Ulvaria, whose image is represented on the cover. During evolution, plant and microbial cells stored the neurotransmitters that play multifunctional roles today. Researchers have paid special attention to their functions in plants, the oxygen well of our planet. This book provides powerful tools for both analyzing and manipulating organisms, considering the functions of neurotransmitters in plant cells and the practical application of knowledge about acetylcholine, catecholamines, serotonin, melatonin, histamine, gamma-aminobutyric acid and glutamine for ecology, agriculture, medicine and food industries. Neurotransmitters in Plants: Perspectives and Applications presents information on: the location and biosynthesis where neurotransmitters occur the molecular biology of some enzymes participating in the process their role in vivo and in vitro processes their functions in plant environmental adaptation in plants their role in enriching the food and medicinal value of plants.


Download Handbook of Toxicology of Chemical Warfare Agents PDF

Handbook of Toxicology of Chemical Warfare Agents

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Publisher : Academic Press
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ISBN 10 : 9780128190913
Pages : 1318 pages
Rating : 4.1/5 (128 users)

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Download or read book Handbook of Toxicology of Chemical Warfare Agents PDF or another Format written by Ramesh C. Gupta and published by Academic Press. This book was released on 2020-03-31 with total page 1318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures. Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more. Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK


Download The Genetic Basis of Sleep and Sleep Disorders PDF

The Genetic Basis of Sleep and Sleep Disorders

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Publisher : Cambridge University Press
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ISBN 10 : 9781107041257
Pages : 413 pages
Rating : 4.0/5 (17 users)

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Download or read book The Genetic Basis of Sleep and Sleep Disorders PDF or another Format written by Paul Shaw and published by Cambridge University Press. This book was released on 2013-10-24 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.


Download Neuropharmacology of Insects PDF

Neuropharmacology of Insects

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Publisher : John Wiley & Sons
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ISBN 10 : 9780470718391
Pages : 192 pages
Rating : 4.7/5 (47 users)

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Download or read book Neuropharmacology of Insects PDF or another Format written by David Evered and published by John Wiley & Sons. This book was released on 2009-09-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.


Download Maturation of the Nervous System PDF

Maturation of the Nervous System

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Publisher : Elsevier
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ISBN 10 : 9780080861739
Pages : 422 pages
Rating : 4.8/5 (8 users)

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Download or read book Maturation of the Nervous System PDF or another Format written by and published by Elsevier. This book was released on 2011-09-22 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maturation of the Nervous System


Download Preparations of Vertebrate Central Nervous System In Vitro PDF

Preparations of Vertebrate Central Nervous System In Vitro

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Publisher : John Wiley & Sons Incorporated
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ISBN 10 : UOM:39015019005332
Pages : 241 pages
Rating : 4.1/5 (39 users)

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Download or read book Preparations of Vertebrate Central Nervous System In Vitro PDF or another Format written by Henrik Jahnsen and published by John Wiley & Sons Incorporated. This book was released on 1990-09-07 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents some of the latest in vitro techniques that can be used to study the vertebrate central nervous system--particularly the brain slice technique. The advent of this new era in neuroscience led to a number of difficult test limitations in the use of this technique, including problems associated with the study of properties in large three-dimensional neural networks and processes lasting longer than 18-24 hours. The authors present solutions to these problems and indicate how it is possible to push in vitro techniques toward their known limits. Invaluable, this work will serve as a stepping-stone to further research and development activity in the neuroscience field.


Download Neurotransmitter Actions in the Vertebrate Nervous System PDF

Neurotransmitter Actions in the Vertebrate Nervous System

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781468449617
Pages : 511 pages
Rating : 4.4/5 (468 users)

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Download or read book Neurotransmitter Actions in the Vertebrate Nervous System PDF or another Format written by Michael Rogawski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intercellular communication via bioactive substances occurs in virtually all multicellular systems. Chemical neurotransmission in the vertebrate nervous system represents a form of signaling of this type. The biology of chemical neurotransmission is complex, involving transmitter synthesis, transport, and release by the presynaptic neuron; signal generation in the target tissue; and mechanisms for termination of the response. The focus of this book is on one aspect of this scheme: the diverse electrophysiological effects induced by different neurotransmitters on targets cells. In recent years, astonishing progress has been made in elucidating the specific physiological signals mediated by neurotransmitters in the verte brate nervous system, yet, in our view, this has not been adequately recog nized, perhaps because the new concepts have yet to filter into neuroscience textbooks. Nevertheless, the principles of neurotransmitter action are critical to advances in many areas of neuroscience, including molecular neurobiol ogy, neurochemistry, neuropharmacology, physiological psychology, and clinical neuroscience. It was the need for a sourcebook that prompted us to engage a group of neurophysiologists to prepare the chapters in this volume. However, there was an additional reason for this book: more and more it seemed that the field, if not yet having reached maturity, at least was ap proaching adolescence, with strengths in some areas and healthy conflicts in others. At this stage of development a textbook can help to define a field, clarify problems to be resolved, and identify areas for future investigation.


Download Habituation PDF

Habituation

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Publisher : Routledge
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ISBN 10 : 9781317265887
Pages : 356 pages
Rating : 4.2/5 (317 users)

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Download or read book Habituation PDF or another Format written by Thomas J. Tighe and published by Routledge. This book was released on 2016-07-15 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1976, this volume is based on a conference held in 1974. The purpose of the conference was to foster communication between those researchers studying habituation or closely related processes in children and those studying habituation at the level of neurophysiology and animal behaviour. Within each of these groups there was burgeoning interest in habituation, yet there had been little, if any, interaction between them. Overall, this volume provides a medium for cross-fertilization between animal-neurophysiological and developmental research on habituation, highlighting some of the current empirical and theoretical concerns within each area at the time. While other volumes may have provided more comprehensive and detailed reviews of aspects of habituation, the juxtaposition of developmental and animal neuro-physiological research provided in this text was unique in the literature at the time.


Download Neural Tissue Transplantation Research PDF

Neural Tissue Transplantation Research

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781461255390
Pages : 243 pages
Rating : 4.2/5 (461 users)

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Download or read book Neural Tissue Transplantation Research PDF or another Format written by R.B. Wallace and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decade research on neural transplantation in mammals has grown extensively, and has attracted the attention of many young inquisitive scientists. This growth, as the critics point out, has been somewhat random, and has resulted neither in the formulation of basic concepts nor in any other significant achievement. For instance, they question-how is it possible to jump into functional research with clinical bearing when the basic morphological work has not yet been conducted? The criticism, objectively speaking, is valid and is supported by the fact that every investigator who has stepped into this unex plored field of neurosciences has formulated questions in his own way, has followed his own "model" oftransplantation, and has arrived at his own unique conclusions. The potential danger, as the critics emphasize, in this type of approach lies in that instead of evolving into a scientifically solid and valuable field of research, it may end in a confusing and conflicting mass of questionable claims and subjective opinions. The present situation, very likely, is a reflection of unrestrained enthusiasm and imaginativeness of the investigators, and the demands of the times for the so-called "newsworthy" and "breakthrough" publications. Despite these limitations, two important facts have been estab lished in this field. First, as far as transplantation of neural tissues per se is concerned, what was considered impossible by some critics about 10-12 years ago has been shown to be possible.


Download Tobacco: The Growing Epidemic PDF

Tobacco: The Growing Epidemic

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781447107699
Pages : 998 pages
Rating : 4.1/5 (447 users)

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Download or read book Tobacco: The Growing Epidemic PDF or another Format written by Rushan Lu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the full proceedings of the Tenth World Conference on Tobacco or Health, held 24-28 August 1997 in Beijing, China, and hosted by the Chinese Association on Smoking and Health and the Chinese Medical Association. Tobacco is now causing a worldwide epidemic of premature death and disability, affecting first men and then women in developed countries, and now increasingly affecting developing countries. The theme "Tobacco: The Growing Epidemic" was chosen to reflect the increasingly global nature of the problem.